Preparation and characterization of Pectin/Polypyrrole based multifunctional coatings on TiNbZr alloy for orthopaedic applications. (15th August 2020)

• Record Type: Journal Article
• Authors: Kumar, A. Madhan; Adesina, Akeem Yusuf; Hussein, M.A.; Umoren, Saviour A.; Ramakrishna, Suresh; Saravanan, S.
• Is Part Of: Carbohydrate polymers. Volume 242(2020)
• Publication Date: 2020-08-15
• Subjects: Pectin -- Polypyrrole -- Biocompatibility -- Antibacterial -- Corrosion -- Coatings; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116285
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Gentamicin loaded Pectin/Polypyrrole coatings were electrochemically prepared. Structural analysis revealed the hydrogen bonding exist amongst pectin, GM and PPy. Corrosion results in SBF validated the improved surface protective performance. The composite coatings enhanced antibacterial activity by sustained release of GM. The composite coatings exhibited adequate biocompatibility to osteosarcoma MG63cell. Abstract: Being a natural and renewable polysaccharide, pectin (PC) is considered a polymer with promising potential for many applications. In the present investigation, novel multifunctional pectin/polypyrrole (PC/PPy) composite coatings loaded with gentamicin (GM) were electrochemically deposited on TiNbZr alloy to enhance its biocompatibility, antibacterial performance and corrosion resistance in physiological environment. Various surface and structural characterization techniques were deployed to examine the composite coatings. in vitro corrosion analysis confirmed that the composite coated TiNbZr specimen exhibited higher corrosion resistant performance in simulated body fluid (SBF). The drug release kinetics was estimated and the results corroborated the sustained release of GM from the controlled degradation of the composite matrix. The pectin composite coatings exhibited effective antibacterial performance; due to the sustained release of GM. In-vitro cell culture studies validated the improved biocompatibility of the composite coatings. Among the developed coatings, composite coatings loaded with 10 wt. % of GM exhibited the lowest corrosion rate, enhanced biocompatibility, and antibacterial performance.