Effect of chitooligosaccharides on human gut microbiota and antiglycation. (15th August 2020)

• Record Type: Journal Article
• Authors: Liu, Wei; Li, Xiaoqiong; Zhao, Zhonglin; Pi, Xionge; Meng, Yanyu; Fei, Dibo; Liu, Daqun; Wang, Xin
• Is Part Of: Carbohydrate polymers. Volume 242(2020)
• Publication Date: 2020-08-15
• Subjects: AGEs advanced glycation end products -- CML Nε-(carboxymethyl) lysine -- COS Chitooligosaccharides -- DIO diet-induced obesity -- GC gas chromatography -- HF high fat -- LDA Linear discriminant analysis -- OTU operational taxonomic unit -- PCoA principal-coordinate analysis -- QIIME quantitative insights into microbial ecology -- q-PCR quantitative real-time PCR -- RDA Redundancy analysis -- SCFAs short chain fatty acids; AGEs -- Antiglycation -- Chitooligosaccharides -- Gut microbiota -- Prebiotics -- SCFA; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116413
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: The biofunctionality of COS was associated with the modification of gut microbiota. Prebiotic effect of COS was related to an increase in Bacteroides and Faecalibacterium, and a decrease in Klebsiella . The increased acetic acid production by COS was positively correlated with Bacteroides abundance. The antiglycation activity of COS and acetic acid was dose-dependent. COS may prevent CML (a marker of AGEs) accumulation in adipose tissue. Abstract: Chitooligosaccharides (COS) have garnered great attention in the field of human healthcare. The prebiotic activities and antiglycation of COS were investigated using a combination of in vitro and in vivo studies. COS supplementation dramatically increased the levels of acetic acid, while reducing the concentrations of propionic and butyric acids. It also decreased the total bacterial population; however, it did not affect diversity and richness of the gut microbiota. In addition, COS modulated the gut microbiota composition by increasing Bacteroidetes, decreasing Proteobacteria and Actinobacteria, and lowering the Firmicutes/Bacteroidetes ratio. COS promoted the generation of beneficial Bacteroides and Faecalibacterium genera, while suppressing the pathogenic Klebsiella genus. The antiglycation activity of COS and acetic acid was dose-dependent. Furthermore, COS prevented the decrease of serum N ε -(carboxymethyl) lysine (CML) level caused by CML ingestion in a mouse model of diet-induced obesity. To improve host health, COS could be potential prebiotics in food products.