Prenatal maternal stress and child hair cortisol four years later: Evidence from a low-income sample. (July 2020)

• Record Type: Journal Article
• Authors: Alen, Nicholas V.; Hostinar, Camelia E.; Mahrer, Nicole E.; Martin, Stephen R; Guardino, Christine; Shalowitz, Madeleine U.; Ramey, Sharon L.; Schetter, Christine Dunkel
• Is Part Of: Psychoneuroendocrinology. Volume 117(2020)
• Publication Date: 2020-07
• Subjects: Prenatal stress -- Maternal stress -- Fetal programming -- Hair cortisol; Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2020.104707
• Languages: English
• ISSNs: 0306-4530

Abstract

Highlights: Maternal prenatal stress during individual points not related to offspring hair cortisol. Maternal stress increases from second to third trimester then decreases. Increases in maternal prenatal stress predicts higher child hair cortisol. Girls and children of African American mothers exhibit higher hair cortisol. Abstract: Background: Maternal stress during pregnancy can influence the trajectory of fetal development, shaping offspring physiology and health in enduring ways. Some research implicates fetal programming of the hypothalamic-pituitary-adrenocortical (HPA) axis as a mediator of these effects. The present study is the first to examine child hair cortisol concentration (HCC) and maternal stress during pregnancy in a diverse, low-income sample. Methods: The sample consisted of 77 healthy, low-income ( M annual income: $13, 321), mother-children pairs ( M child age = 3.81 years, SD = 0.43). The children were 57 % girls, 43 % boys. Mothers were 65 % Latina/Hispanic, 28 % Non-Hispanic White, 7% Black/African American. Maternal prenatal stress was measured with the Perceived Stress Scale administered by interview in the second and third trimesters, and again approximately four years later when child hair samples for assaying HCC were collected. Results: On average maternal perceived stress increased significantly across pregnancy, then returned to lower levels 4 years after birth. Regression analysis revealed that child HCC was not significantly predicted by maternal perceived stress at either single prenatal time point. Exploratory analysis revealed evidence of a relation between increases in maternal prenatal stress from second to third trimester and child HCC four years later ( r = .37, p = .04). Conclusions: These results suggest that measures of prenatal maternal stress at any one time point may not be predictive of offspring long-term HPA output in low-income child samples, but that increases in stress levels across pregnancy may provide important information undetected by individual time point measures.