Fatal hemolytic disease of the fetus and newborn caused by anti-Jra antibody: A case report and literature review. (February 2020)

• Record Type: Journal Article
• Authors: Kim, Min-Sun; Kim, Jin Seok; Park, Hyewon; Chung, Yousun; Kim, Hyungsuk; Ko, Dae-Hyun; Hwang, Sang-Hyun; Won, Hye-Sung; Oh, Heung-Bum
• Is Part Of: Transfusion and apheresis science. Volume 59:Number 1(2020)
• Publication Date: 2020-02
• Subjects: Fatality -- Hemolytic disease of the fetus and newborn -- Anti-Jra -- ABCG2; Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2019.06.029
• Languages: English
• ISSNs: 1473-0502

Abstract

Abstract: The Jr a antigen of the JR blood group system is a highly prevalent red blood cell antigen. Although anti-Jr a –associated hemolytic disease of the fetus and newborn (HDFN) is generally considered mild-to-moderate, a rare fatal case was recently reported. We report the third example of HDFN-related anti-Jr a with fatal outcomes. The clinical significance of anti-Jr a antibody as a cause of HDFN should be reassessed.