Homo-Oligomerisation in Signal Transduction: Dynamics, Homeostasis, Ultrasensitivity, Bistability. (21st August 2020)

• Record Type: Journal Article
• Authors: Koch, Daniel
• Is Part Of: Journal of theoretical biology. Volume 499(2020)
• Publication Date: 2020-08-21
• Subjects: Protein complexes -- Mathematical modelling -- Dynamic signal encoding -- Post-translational modifications -- Multi-enzyme systems; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2020.110305
• Languages: English
• ISSNs: 0022-5193

Abstract

Graphical abstract: Highlights: Homo-oligomerisation may offer an unexpected variety of signal processing functions. These include: dynamic signal encoding via oligomeric complex size. Homeostatic regulation of monomer concentration. Bistability via pseudo-multisite modification and multi-enzyme regulation. The findings partly explain why homo-oligomerisation is so commonly found in evolution. Abstract: Homo-oligomerisation of proteins is a ubiquitous phenomenon whose exact role remains unclear in many cases. To identify novel functions, this paper provides an exploration of general dynamical mathematical models of homo-oligomerisation. Simulation and analysis of these models show that homo-oligomerisation on its own allows for a remarkable variety of complex dynamic and steady state regulatory behaviour such as transient overshoots or homeostatic control of monomer concentration. If post-translational modifications are considered, however, conventional mass action kinetics lead to thermodynamic inconsistencies due to asymmetric combinatorial expansion of reaction routes. Introducing a conservation principle to balance rate equations re-establishes thermodynamic consistency. Using such balanced models it is shown that oligomerisation can lead to bistability by enabling pseudo-multisite modification and kinetic pseudo-cooperativity via multi-enzyme regulation, thereby constituting a novel motif for bistable modification reactions. Due to these potential signal processing capabilities, homo-oligomerisation could play far more versatile roles in signal transduction than previously appreciated.