Carbon ion radiotherapy in pancreatic cancer: A review of clinical data. (June 2020)

• Record Type: Journal Article
• Authors: Liermann, Jakob; Shinoto, Makoto; Syed, Mustafa; Debus, Jürgen; Herfarth, Klaus; Naumann, Patrick
• Is Part Of: Radiotherapy and oncology. Volume 147(2020)
• Page Start: 145
• Page End: 150
• Publication Date: 2020-06
• Subjects: LAPC Locally advanced pancreatic cancer -- GITISG Gastrointestinal Tumor Study Group -- SMF (Chemotherapy regimen consisting of) Streptozosin, Mitomycin and 5-Fluorouracil -- NCCN National Comprehensive Cancer Network -- N Number (of patients) -- Fx (number of radiotherapy) Fractions -- OS Overall survival -- Yr Year -- OAR Organ at risk -- IMRT Intensity-modulated radiotherapy -- SBRT Stereotactic body radiotherapy -- LET Linear energy transfer -- RBE Relative biological effectiveness -- HIMAC Heavy Ion Medical Accelerator in Chiba -- HIT Heidelberg Ion Beam Therapy Center -- GSI GSI Helmholtzzentrum für Schwerionenforschung -- LEM Local effect model -- GTV Gross tumor volume -- CTV Clinical target volume -- NIRS National Institute of Radiological Sciences -- FOLFIRINOX (Chemotherapy regimen consisting of) 5-Fluorouracil, Leucovorin, Irinotecan, and Oxaliplatin -- LPFS Local progression free survival -- FDG Desoxy-2-[18 F]fluoro-D-glucose -- PET Positron emission tomography; Pancreatic cancer -- Carbon ion radiotherapy -- Particle therapy -- Radiotherapy; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2020.05.012
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: Clinical trials in pancreatic cancer. Efficacy of carbon ion radiotherapy in pancreatic cancer. Summary of carbon ion radiotherapy in pancreatic cancer. Abstract: Despite all efforts, pancreatic cancer remains a highly lethal disease. Only surgical resection offers a realistic chance of survival. But at diagnosis the majority of patients suffer from unresectable disease. Whereas guidelines clearly recommend systemic treatments in metastatic disease, data is limited to support a specific treatment option for locally advanced or borderline resectable pancreatic cancer. Therefore, there is an urgent need to improve treatment schemes addressing patients that suffer from unresectable pancreatic cancer. Chemotherapy, photon radiotherapy and combinations of both have shown improved local control rates but there is still a lack of evidence demonstrating an overall survival benefit of photon radiotherapy if no surgical resection is achieved. Impressive results of Japanese Phase I/II-trials investigating carbon ion radiotherapy in pancreatic cancer attracted global attention. Several studies have been initiated to validate and intensify this promising issue. This review gives an overview of the evidence and current use of carbon ion radiotherapy in pancreatic cancer.