Total and subcellular Ti distribution and detoxification processes in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil. (April 2020)

• Record Type: Journal Article
• Authors: Monteiro, Fernanda; Lemos, Leila S.; de Moura, Jailson Fulgêncio; Rocha, Rafael Christian Chávez; Moreira, Isabel; Di Beneditto, Ana Paula M.; Kehrig, Helena A.; Bordon, Isabella C.; Siciliano, Salvatore; Saint'Pierre, Tatiana D.; Hauser-Davis, Rachel Ann
• Is Part Of: Marine pollution bulletin. Volume 153(2020)
• Publication Date: 2020-04
• Subjects: TiO2 nanoparticles -- Bioavailability -- Titanium -- Delphinids -- Metalloproteins -- Detoxification; Marine pollution -- Periodicals; Marine Biology -- Periodicals; Water Pollution -- Periodicals; Mer -- Pollution -- Périodiques; Publications périodiques; Pollution des mers; Lutte antipollution; Electronic journals; 363.7394
• DOI: 10.1016/j.marpolbul.2020.110975
• Languages: English
• ISSNs: 0025-326X

Abstract

Abstract: Titanium (Ti), used in many dailyuse products, such as shampoos and sunscreen filters, in the form of TiO2 nanoparticles (NPs), may elicit adverse marine biota effects. Marine mammal Ti data is scarce, and subcellular distribution and detoxification information is non-existent. Ti concentrations and metalloprotein detoxification in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil were assessed. Metallothionein (MT) concentrations were determined spectrophotometrically, total and subcellular Ti, by ICP-MS and detoxification, by HPLC-ICP-MS. Ti detoxification occurred through MT complexation. Statistical Ti-MT associations were observed in S. bredanensis liver, indicating TiO2 NPs contamination, as Ti binds to MT only as NPs. MT-Ti correlations were observed for both the coastal ( P. blainvillei ) and offshore ( S. bredanensis ) dolphins, evidencing oceanic TiO2 diffusion. Ti detoxification through binding to reduced glutathione occurred in both species. Thermostable subcellular fractions are a valuable tool for cetacean Ti detoxification assessments and should be applied to conservation efforts. Highlights: Ti content and detoxification were assessed in coastal and offshore dolphin species. Ti detoxification through MT complexation was observed in both species. TiO2 NPs contamination was detected through statistical Ti-MT associations. Oceanic TiO2 diffusion was evidenced through MT-Ti correlations. Ti detoxification through binding to reduced glutathione occurred in both species.