Nasal colonization with Staphylococcus aureus is a risk factor for ventricular assist device infection in the first year after implantation: A prospective, single-centre, cohort study. Issue 5 (May 2020)

• Record Type: Journal Article
• Authors: Nurjadi, Dennis; Last, Katharina; Klein, Sabrina; Boutin, Sébastien; Schmack, Bastian; Mueller, Florian; Heeg, Klaus; Ruhparwar, Arjang; Heininger, Alexandra; Zanger, Philipp
• Is Part Of: Journal of infection. Volume 80:Issue 5(2020)
• Page Start: 511
• Page End: 518
• Publication Date: 2020-05
• Subjects: (MeSH): Heart-Assist Devices -- Survival Analysis -- Risk Factors -- Infection Control -- Heart Failure -- Cardiovascular Surgical Procedures -- Methicillin-Resistant Staphylococcus aureus -- Microbiota -- Cohort Studies -- Whole Genome Sequencing; Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2020.02.015
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: S. aureus was the most common cause of ventricular-assist-device (VAD) infections. Nasal colonization increased the risk of S. aureus -VAD-infection about 4-fold. All VAD-infections occurred at least 7 weeks after implantation. Genotyping showed that 75% of infecting S. aureus was from endogenous origin. Sustained interruption of endogenous transmission may half burden of VAD-infections. Summary: Objectives: To assess, whether S. aureus nasal colonization is a risk factor for infections in patients with durable ventricular assist device (VAD). Methods: Prospective, single-centre, cohort study (i) ascertaining S. aureus nasal colonization status of patients admitted for VAD-implantation and detecting time to first episode of VAD-specific or -related infection according to International Society for Heart and Lung Transplantation criteria during follow-up and (ii) comparing whole genomes of S. aureus from baseline colonization and later infection. Results: Among 49 patients (17 colonized, 32 non-colonized), S. aureus VAD-infections occurred with long latency after implantation (inter quartile range 76–217 days), but occurred earlier (log-rank test P = 0.006) and were more common (9/17, 52.9% vs. 4/32, 12.5%, P = 0.005; incidence rates 2.81 vs. 0.61/1000 patient days; incidence rate ratio 4.65, 95% confidence interval 1.30–20.65, P = 0.009) among those nasally colonized with S. aureus before implantation. We found a similar but less pronounced effect of colonization status when analysing its effect on all types of VAD-infections (10/17, 58.8% vs. 7/32, 21.9%, P = 0.01). These findings remained robust when adjusting for potential confounders and restricting the analysis to 'proven infections'. 75% (6/8) of paired S. aureus samples from colonization and VAD-infection showed concordant whole genomes. Conclusions: In patients with durable VAD, S. aureus nasal colonization is a source of endogenous infection, often occurring months after device-implantation and affecting mostly the driveline. Hygiene measures interrupting the endogenous route of transmission in VAD-patients colonized with S. aureus long-term may about half the burden of infections and require clinical scrutiny. Graphical abstract: Image, graphical abstract