Cutaneous lymphoma in Japan, 2012–2017: A nationwide study. Issue 3 (March 2020)

• Record Type: Journal Article
• Authors: Fujii, Kazuyasu; Hamada, Toshihisa; Shimauchi, Takatoshi; Asai, Jun; Fujisawa, Yasuhiro; Ihn, Hironobu; Katoh, Norito
• Is Part Of: Journal of dermatological science. Volume 97:Issue 3(2020)
• Page Start: 187
• Page End: 193
• Publication Date: 2020-03
• Subjects: ATLL Adult T-cell leukemia/lymphoma -- BPDCN blastic plasmacytoid dendritic cell neoplasm -- CBCL cutaneous B-cell lymphoma -- CL cutaneous lymphoma -- CTCL cutaneous T-cell lymphoma -- DLBCL diffuse large B-cell lymphoma -- ELD extensive limb disease -- ENKL extranodal NK/T-cell lymphoma nasal type -- HTLV-1 human T-cell lymphotropic virus type 1 -- ISCL International Society for Cutaneous Lymphomas -- IVLBCL intravascular large B-cell lymphoma -- MF mycosis fungoides -- NK natural killer -- OIIA-LPD other iatrogenic immunodeficiency-associated lymphoproliferative disorders -- PC CD30+ LPD primary cutaneous CD30+ T-cell lymphoproliferative disorders -- PCALCL primary cutaneous anaplastic large cell lymphoma -- PCDLBCL, LT primary cutaneous diffuse large B-cell lymphoma leg type -- PCFCL primary cutaneous follicle center lymphoma -- PCL primary cutaneous lymphoma -- PCMZL extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue -- SCL secondary cutaneous lymphoma -- SPTCL subcutaneous panniculitis-like T-cell lymphoma -- SS Sézary syndrome -- TNM tumor–node–metastasis; Cutaneous lymphoma -- Epidemiological data -- Japanese skin cancer -- Systemic lymphoma -- Incidence; Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2020.01.010
• Languages: English
• ISSNs: 0923-1811

Abstract

Highlights: In 2012–2017, 2547 new Japanese patients with cutaneous lymphoma were registered. Mycosis fungoides was the most common subtype among patients (48.0 %). Compared with previous registry data, B-cell cutaneous lymphoma cases increased. This analysis provides insight into the pattern of cutaneous lymphoma in Japan. Abstract: Background: The types of cutaneous lymphoma (CL) and their incidences can vary among geographic areas or ethnic groups. Objective: This study aimed to investigate the incidence of various CL types in Japan using epidemiological data from a nationwide registration system for CL. Methods: A questionnaire was sent to participating hospitals, all of which had been approved to conduct residency programs for board-certified dermatologists by the Japanese Dermatological Association. Data from patients newly diagnosed with CL were collected electronically. Results: Between 2012 and 2017, 2547 new patients with CL from the dermatological institutes were registered. In total, 2090 patients had primary CL and 453 had secondary CL. Those with primary CL included 1609 (77.0 %) patients with mature T- and natural killer (NK)-cell neoplasms, 442 (21.1 %) with B-cell neoplasms, and 39 (1.9 %) with blastic plasmacytoid dendritic cell neoplasms. Mycosis fungoides (MF) was the most common CL subtype in the present study (1003 patients, 48.0 %), and 72.4 % of MF patients had early-stage disease, similar to observations in previous studies on other cohorts. Primary cutaneous CD30+ T-cell lymphoproliferative disorders and adult T-cell leukemia/lymphoma were the second and third most common subtypes, respectively. Conclusion: Compared to that in our previous cohort (2007–2011), the number of registered T- and NK-cell CL cases decreased, whereas that of B-cell CL cases increased from 44.8–73.7 patients/year. These results provide insight into CL trends within the Japanese population, which might contribute to a better understanding of the disease.