Hypolipidemic constituents from the aerial portion of Sibiraea angustata. Issue 11 (1st June 2020)

• Record Type: Journal Article
• Authors: Liu, Hongdong; Zhang, Ting; Jiang, Piao; Zhu, Weifeng; Yu, Songhua; Liu, Yong; Li, Bin; Li, Fei
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 30:Issue 11(2020)
• Publication Date: 2020-06-01
• Subjects: Sibiraea angustata -- Monoterpene acylglucoside -- Hypolipidemic effect -- Lipidomics; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2020.127161
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Two new monoterpene acylglucosides (1 –2 ) and one new aromatic glycoside (3 ), together with five known compounds (4 –8 ), were isolated from 95% ethanol extract of Sibiraea angustata . The structures of these compounds were characterized by 2D-NMR and mass spectrometry. Compounds were evaluated for their hypolipidemic activity using oleic acid-induced lipid accumulation in HepG2 cells. RT-PCR analysis revealed that compound 5 could decrease the expression level of fatty acid synthase (FASN). Lipidomics analysis indicated that compound 5 significantly decreased the levels of 11 lipids in oleic acid-induced lipid accumulation, including triglycerides (TG), diglycerides (DG), phosphatidylcholines (PC) and 1-acyl-sn-glycero-3-phosphocholines (lysoPC). These data demonstrated that terpene acylglucosides are the major active constituents in Sibiraea angustata .