Cancer stem cells and their unique role in metastatic spread. (February 2020)

• Record Type: Journal Article
• Authors: Steinbichler, Teresa Bernadette; Savic, Dragana; Dudás, József; Kvitsaridze, Irma; Skvortsov, Sergej; Riechelmann, Herbert; Skvortsova, Ira-Ida
• Is Part Of: Seminars in cancer biology. Volume 60(2020)
• Page Start: 148
• Page End: 156
• Publication Date: 2020-02
• Subjects: Dormancy -- Stem cell niche -- Angiogenesis -- EMT -- Migration -- Invasion; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2019.09.007
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation, but also dormancy and cellular plasticity that allow adaption to new environmental circumstances. These abilities are ideal prerequisites for the successful establishment of metastasis. This review highlights the role of CSCs in every step of the metastatic cascade from cancer cell invasion into blood vessels, survival in the blood stream, attachment and extravasation as well as colonization of the host organ and subsequent establishment of distant macrometastasis.