Headache intensity is associated with increased white matter lesion burden in CADASIL patients. (March 2020)

• Record Type: Journal Article
• Authors: Tábuas-Pereira, Miguel; Varela, Ricardo; Beato-Coelho, José; Maleita, Diogo; Ferreira, Carlos; d'Almeida, Otília C.; Nunes, César; Luzeiro, Isabel; Santo, Gustavo C.
• Is Part Of: Journal of clinical neuroscience. Volume 73(2020)
• Page Start: 179
• Page End: 182
• Publication Date: 2020-03
• Subjects: CADASIL -- Ischemia -- Vascular -- Female -- Pain; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2019.11.025
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: The prevalence of migraine with atypical aura is lower in our sample than in the series reported in the literature. Headache intensity is a predictor of white matter hyperintensities burden in CADASIL patients. This study substantiate previous reports of increased burden of white matter hyperintensities in females. Abstract: Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cause of vascular dementia in adults. Migraine is a major symptom of the disease. We aimed to identify clinical and demographical features of the headache associated with increased cerebral lesion burden in a cohort of CADASIL patients. Methods: Thirty-two patients with CADASIL were enrolled in this cross-sectional study. Demographics data, vascular risk factors and headache characteristics were collected through a structured questionnaire. MRI (3-T) was used to determine white matter hyperintensities burden evaluated by its volume (WMH-V). Results: Regression analysis showed that age (β = 1.266, 95%CI = [0.805, 1.726], p < 0.001), headache intensity (β = 5.143, 95%CI = [2.362, 7.924], p = 0.001) and female sex (β = 19.727, 95%CI = [8.750, 30.075], p = 0.001) were the main predictors of WMH-V. Discussion: Age, female sex and headache intensity are associated with increased white matter lesion volume in CADASIL.