Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder. (June 2020)

• Record Type: Journal Article
• Authors: Voon, Valerie; Grodin, Erica; Mandali, Alekhya; Morris, Laurel; Doñamayor, Nuria; Weidacker, Kathrin; Kwako, Laura; Goldman, David; Koob, George F.; Momenan, Reza
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 113(2020)
• Page Start: 492
• Page End: 506
• Publication Date: 2020-06
• Subjects: Neuroimaging -- Alcohol use disorder -- Alcohol dependence -- Binge drinking -- MRI -- PET; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2020.04.004
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Disorders of addiction can be characterizd by aberrant neurocircuitry. Multi-modal human imaging can be integrated within a model of cognitive mechanisms corresponding with addiction cycle stages. Neuroimaging can provide insights into the underlying neural mechanisms and potential role in treatment prediction. Abstract: Alcohol misuse and addiction are major international public health issues. Addiction can be characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic and social factors. Neuroimaging in alcohol misuse can thus provide a critical window into underlying neural mechanisms, highlighting possible treatment targets and acting as clinical biomarkers for predicting risk and treatment outcomes. This neuroimaging review on alcohol misuse in humans follows the Addictions Neuroclinical Assessment (ANA) that proposes incorporating three functional neuroscience domains integral to the neurocircuitry of addiction: incentive salience and habits, negative emotional states, and executive function within the context of the addiction cycle. Here we review and integrate multiple imaging modalities focusing on underlying cognitive processes such as reward anticipation, negative emotionality, cue reactivity, impulsivity, compulsivity and executive function. We highlight limitations in the literature and propose a model forward in the use of neuroimaging as a tool to understanding underlying mechanisms and potential clinical applicability for phenotyping of heterogeneity and predicting risk and treatment outcomes.