Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART). (August 2020)

• Record Type: Journal Article
• Authors: Facchinetti, Fabio; Unfer, Vittorio; Appetecchia, Marialuisa; Aragona, Cesare; Bertelli, Matteo; Bevilacqua, Arturo; Espinola, Maria Salome Bezerra; Bizzarri, Mariano; Cavalli, Pietro; Copp, Andrew; D'Anna, Rosario; Dewailly, Didier; Greene, Nicholas; Marín, Imelda Hernández; Kamenov, Zdravko A.; Kandaraki, Eleni; Diamanti-Kandarakis, Evanthia; Laganà, Antonio Simone; Monastra, Giovanni; Oliva, Mario Montanino; Nestler, John E.; Ozay, Ali Cenk; Papalou, Olga; Pkhaladze, Lali; Porcaro, Giusy; Prapas, Nikos; Soulage, Christophe O.; Stringaro, Annarita; Vazquez-Levin, Mónica; Wdowiak, Artur; Facchinetti, Fabio; Espinola, Maria Salome Bezerra; Dewailly, Didier; Ozay, Ali Cenk; Prapas, Nikos; Vazquez-Levin, Mónica; Wdowiak, Artur; Unfer, Vittorio;
• Is Part Of: Trends in endocrinology and metabolism. Volume 31:Number 8(2020)
• Page Start: 570
• Page End: 579
• Publication Date: 2020-08
• Subjects: myo-inositol -- D-chiro-inositol, polycystic ovary syndrome -- infertility -- assisted reproductive treatment -- in vitro fertilization; Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2020.04.003
• Languages: English
• ISSNs: 1043-2760

Abstract

Abstract : It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART). Highlights: MI and DCI are insulin second messengers, but have different functions. MI is involved primarily in cellular glucose uptake (e.g., the ovary, testis, and epididymis contain high concentrations of MI). By contrast, DCI levels are high in tissues where glycogen is stored (e.g., liver and muscle). In the ovary, MI acts also as a second messenger downstream of follicle-stimulating hormone. MI is involved in cell proliferation and improves oocyte and embryo quality. Unlike MI, there are no data on the effects of DCI on sperm quality and on the first phases of fertilization and development, whereas high concentrations of DCI in the ovary are detrimental to oocyte and blastocyst quality. MI also plays a pivotal role in male fertility at both the physiological and therapeutic levels. MI oral supplementation during controlled ovarian stimulation and ART reduces the total amount of gonadotropins used and the length of controlled ovarian hyperstimulation in both PCOS and non-PCOS women.