Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report. (2020)

• Record Type: Journal Article
• Authors: Tokuyasu, Hirokazu; Horie, Mika; Ishikawa, Soichiro; Sakai, Hiromitsu; Miura, Hiroshi; Yamasaki, Akira
• Is Part Of: Respiratory medicine case reports. Volume 29(2020)
• Publication Date: 2020
• Subjects: Adenocarcinoma -- Epidermal growth factor receptor -- Programmed death-ligand 1 -- Programmed death-1 inhibitors -- Squamous cell carcinoma -- Synchronous multiple primary lung cancers; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2019.100976
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: We herein report a non-smoking 81-year-old man with advanced synchronous multiple primary lung cancers (SMPLC), containing squamous cell carcinoma with strong programmed death-ligand 1 expression in the middle lobe and adenocarcinoma with epidermal growth factor receptor (EGFR) exon 19 deletion in the lower lobe. Programmed death-1 (PD-1) inhibitors were administered as first-line chemotherapy; however, treatment response was poor response. There have been no reported SMPLC cases similar to this. During treatment, his non-smoking status and EGFR deletion might have been the cause of the patient's poor response to first-line PD-1 inhibitor treatment.