Parenchymal pressure injury Ca2+ entry mechanism in pancreatitis. (June 2020)

• Record Type: Journal Article
• Authors: Sutton, Robert
• Is Part Of: Cell calcium. Volume 88(2020)
• Publication Date: 2020-06
• Subjects: [Ca2+]i cytosolic Ca2+ concentration -- [Ca2+]m mitochondrial Ca2+ concentration -- CADPR cyclic ADP ribose -- CCK1R high affinity cholecystokinin receptor -- CYPD cyclophilin D -- GPBAR G protein-coupled bile acid receptor 1 -- IP3 inositol trisphosphate -- IP3R inositol trisphosphate receptor -- M3R muscarinic type 3 acetylcholine receptors -- MCU mitochondrial Ca2+ uniporter -- MPTP mitochondrial permeability transition pore -- NAADP nicotinic acid adenine dinucleotide phosphate -- NCX Na+/Ca2+ exchanger -- ORAI1 Ca2+ release-activated Ca2+ channel protein 1 -- Piezo1 Piezo-type mechanosensitive ion channel component 1 -- PMCA plasma membrane Ca2+-ATPase pump -- RYR ryanodine receptor -- SARAF store-operated Ca2+ entry associated regulatory factor -- SERCA sarco-endoplasmic reticulum Ca2+-ATPase pump -- STIM1 stromal interaction molecule 1 -- TRPC transient receptor potential canonical cation channel -- TRPV4 transient potential vanilloid cation channel 4; Piezo1 -- TRPV4 -- Orai1 -- Ca2+overload -- pancreatitis -- drug target; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2020.102208
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: Pancreatic trauma and high parenchymal pressure have been found to open Piezo1 plasma membrane Ca 2+ channels to such an extent that transient receptor potential vanilloid type 4 channels also open to further Ca 2+ entry, overloading the cell with Ca 2+ to induce acute pancreatitis (Swain et al, J Clin Invest, 2020). Elucidation of this mechanism is an important step in understanding pancreatitis and opens up new possibilities for prevention and treatment.