Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?. Issue 126 (May 2020)
- Record Type:
- Journal Article
- Title:
- Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?. Issue 126 (May 2020)
- Main Title:
- Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?
- Authors:
- Long, Chunqin
Xu, Huaxiang
Shen, Qinglin
Zhang, Xianghai
Fan, Bing
Wang, Chuanhong
Zeng, Bingliang
Li, Zicong
Li, Xiaofen
Li, Honglu - Abstract:
- Highlights: The COVID-19 outbreak highlights the need for early diagnosis, isolation and treatment The sensitivity of the CT was 97.2%, while the sensitivity of initial rRT-PCR was 83.3%. Patients with typical CT findings but negative rRT-PCR results should be isolated. Abstract: Purpose: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia. Methods: This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. Results: A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%. Conclusion: rRT-PCR may produce initial false negative results. We suggest that patients with typical CTHighlights: The COVID-19 outbreak highlights the need for early diagnosis, isolation and treatment The sensitivity of the CT was 97.2%, while the sensitivity of initial rRT-PCR was 83.3%. Patients with typical CT findings but negative rRT-PCR results should be isolated. Abstract: Purpose: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia. Methods: This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. Results: A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%. Conclusion: rRT-PCR may produce initial false negative results. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis. … (more)
- Is Part Of:
- European journal of radiology. Issue 126(2020)
- Journal:
- European journal of radiology
- Issue:
- Issue 126(2020)
- Issue Display:
- Volume 126, Issue 126 (2020)
- Year:
- 2020
- Volume:
- 126
- Issue:
- 126
- Issue Sort Value:
- 2020-0126-0126-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-05
- Subjects:
- GGOs ground-glass opacities -- CT computed tomographic -- HRCT high-resolution CT -- COVID-19 Coronavirus Disease 19 -- HCT hematocrit -- GLU glucose -- WHO World Health Organization -- ARDS acute respiratory distress syndrome -- rRT-PCR real-time reverse-transcriptase-polymerase chain reaction -- MERS Middle East Respiratory Syndrome
Severe Acute Respiratory Syndrome -- Coronavirus -- Pneumonia -- Tomography -- X-Ray Computed
Medical radiology -- Periodicals
Radiology -- Periodicals
Radiologie médicale -- Périodiques
Medical radiology
Periodicals
616.075705 - Journal URLs:
- http://www.sciencedirect.com/science/journal/0720048X ↗
http://www.elsevier.com/homepage/elecserv.htt ↗
http://www.clinicalkey.com/dura/browse/journalIssue/0720048X ↗
http://www.clinicalkey.com.au/dura/browse/journalIssue/0720048X ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.ejrad.2020.108961 ↗
- Languages:
- English
- ISSNs:
- 0720-048X
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- Legaldeposit
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