Solubility of naftopidil in pure and mixed solvents at 273.15–313.15 K and its correlation with the Jouyban-Acree and CNIBS/R-K models. (June 2020)

• Record Type: Journal Article
• Authors: Li, Rongrong; Tang, Tian; Yin, Xianfang; Yao, Lusha; Lin, Zhipeng; Zhang, Lin; Gao, Xin; Xu, Xiaojing; Zhao, Jia; Han, Deman
• Is Part Of: Journal of chemical thermodynamics. Volume 145(2020)
• Publication Date: 2020-06
• Subjects: Naftopidil -- Solubility -- Thermodynamic models -- Thermodynamic properties; Thermodynamics -- Periodicals; Thermochemistry -- Periodicals; Thermodynamique -- Périodiques; Thermochimie -- Périodiques; Thermochemistry; Thermodynamics; Periodicals; 541.369
• DOI: 10.1016/j.jct.2019.105969
• Languages: English
• ISSNs: 0021-9614

Abstract

Graphical abstract: Highlights: Research the dissolution behavior of naftopidil in pure and mixed solvents. Extended Hildebrand Solubility Approach was used to explain co-solvence phenomenon. The solubility data were correlated by some thermodynamic models. Some apparent thermodynamic properties were evaluated. Abstract: The dissolution behavior of naftopidil in methanol, ethanol, ethyl acetate, toluene, acetone, acetonitrile and two mixtures of (ethyl acetate + methanol) and (ethyl acetate + ethanol) was studied. In pure and mixed solvents, the solubility was determined experimentally and correlated by some thermodynamic models. The maximum data was obtained at 313.15 K in toluene, and the minimum data was obtained at 273.15 K in acetonitrile. Moreover, there is co-solvence phenomenon in two co-solvent mixtures, the values increased monotonically with the increasing temperature, while increased with increasing co-solvent (ethyl acetate) mass fraction ( w ) to a maximum value at w = 0.8 and then decreased. The dissolution behavior of naftopidil in pure was explained by the properties of solvents such as the hydrogen bond acidity, hydrogen bond basicity, dipolarity/polarizability, and it was evaluated by Extended Hildebrand Solubility Approach in mixed solvents. Besides, the apparent dissolution standard enthalpy ( Δ H sol o ), apparent molar standard Gibbs energy ( Δ G sol o ) and apparent dissolution standard entropy ( Δ S sol o ) of naftopidil in pure and mixed solvents were also calculated.