Controlled release of poorly water soluble anticancerous drug camptothecin from magnetic nanoparticles. (2020)

• Record Type: Journal Article
• Authors: Patil, A.R.; Nimbalkar, M.S.; Patil, P.S.; Chougale, A.D.; Patil, P.B.
• Is Part Of: Materials today. Volume 23:Part 2(2020)
• Page Start: 437
• Page End: 443
• Publication Date: 2020
• Subjects: Coprecipitation -- Magnetic Nanoparticles -- Functionalization -- APTES -- Camptothecin -- Drug release; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2020.02.064
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: The bioavailability of poorly water-soluble anticancerous drug camptothecin (CPT) was improved by its conjugation with magnetic nanoparticles (MNPs). For this the surface of MNPs was modified by (3-aminopropyl)triethoxysilane (APTES) to obtain free amino groups at the end. These surface modified MNPs (MNP-APTES) were used for drug loading. Bare MNPs and MNP-APTES were characterized by X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, Field Emission Scanning Electron Microscopy (FESEM) and Vibrating Sample Magnetometer (VSM). The loading and release behavior of CPT from MNP-APTES was also investigated.