Black phosphorus modified soluble microneedle patch for painless, effective and accurate body slimming. (June 2020) - Peng, Haichuan
Graphical abstract: Rosiglitazone (Rosi)-loaded soluble microneedle (MN) patch is modified with black phosphorus. After MN patch is attached to the target area, Rosi will release to the adipose tissue efficiently under NIR irradiation. Thus, a painless and efficient method to achieve accurate body slimming is realized. Highlights: An nonsurgical and precise weight-loss strategy. Microneedle patches modified with nano black phosphorus. Transformation and consumption of adipose tissue. Dynamic compensation of adipose tissue. Abstract: Compared with painful and difficult overall weight-loss, a surgery-free method was developed to achieve local accurate body slimming. A layer of black phosphorus was modified on the back of the rosiglitazone (Rosi)-loaded soluble microneedle patch. Under near-infrared (NIR) irradiation, Rosi could be delivered to the target adipose tissues efficiently and painlessly, thus achieving accurate body slimming. Based on the experiments in a mouse model with high-fat-induced obesity, after one month, the mice lost about 8% of their body weight while their waist circumference (target region) dropped about 21%. In addition, an interesting phenomenon of adipose tissue dynamic compensation was discovered and discussed for the first time.