Associations of polymorphisms in interleukins with susceptibility to breast cancer: Evidence from a meta-analysis. (June 2020)

• Record Type: Journal Article
• Authors: Xu, Guanghua; Wang, Fengyong
• Is Part Of: Cytokine. Volume 130(2020)
• Publication Date: 2020-06
• Subjects: Interleukins -- Polymorphisms -- Breast cancer (BC) -- Meta-analysis -- East Asians; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2020.154988
• Languages: English
• ISSNs: 1043-4666

Abstract

Abstract: Background: Associations between polymorphisms in interleukins and breast cancer (BC) were already investigated by many studies, yet with controversial findings. The aim of this meta-analysis was to better clarify associations between polymorphisms in interleukins and BC by combing the results of all relevant articles. Methods: Eligible articles were searched from Pubmed, Embase, Web of Science and CNKI. We used Review Manager to combine the results of eligible studies. Results: Fifty-seven studies were included in this meta-analysis. We found that IL-6 rs1800796 (dominant comparison: OR = 0.70, 95% CI 0.53–0.92), IL-8 rs4073 (dominant comparison: OR = 0.74, 95% CI 0.61–0.89; over-dominant comparison: OR = 1.16, 95% CI 1.05–1.29; allele comparison: OR = 0.82, 95% CI 0.69–0.89), IL-10 rs1800896 (recessive comparison: OR = 1.28, 95% CI 1.12–1.47) and IL-18 rs1946518 (dominant comparison: OR = 0.80, 95% CI 0.65–0.97; allele comparison: OR = 0.74, 95% CI 0.59–0.93) polymorphisms were all significantly associated with BC in overall combined analyses. In subgroup analyses, we noticed that IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800896, IL-18 rs1946518 and rs187238 polymorphisms were all significantly associated with susceptibility to BC in East Asians from China. Conclusions: Collectively, this meta-analysis demonstrated that IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800896, IL-18 rs1946518 and rs187238 polymorphisms may confer susceptibility to BC for East Asians from China.