Autophagy regulation as a promising approach for improving cancer immunotherapy. (10th April 2020)

• Record Type: Journal Article
• Authors: Ishimwe, Nestor; Zhang, Wenbin; Qian, Jieying; Zhang, Yunjiao; Wen, Longping
• Is Part Of: Cancer letters. Volume 475(2020)
• Page Start: 34
• Page End: 42
• Publication Date: 2020-04-10
• Subjects: Autophagy modulation -- Immunogenic cell death -- Cytotoxic T lymphocyte -- Immune response -- Tumor microenvironment; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2020.01.034
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and response to antigen; however, autophagy in immune cells may be beneficial or detrimental depending on the developmental stage of the cell and more specifically its degree of differentiation. Autophagy-deficient hosts present variations in many metabolites, proteins and enzymes that may have tumor-promoting or -inhibiting effects. The centrality of autophagy in the metabolism of some cancers and immune cells poses as a critical target whose mechanisms must be further unraveled to optimize patient response and prevent tumor recurrence. Highlights: Immune cells signaling pathways are activated by extracellular and intracellular signals. Autophagy regulators may dictate immune cells response. Combinatorial treatment strategy of autophagy modulators and other cancer drugs pertain a potential future cancer therapy. Autophagy modulators contribute to immune cells activation.