Mn(II) complex of a di-2-pyridyl ketone-N(4)-substituted thiosemicarbazone: Versatile biological properties and naked-eye detection of Fe2+ and Ru3+ ions. (1st March 2020)

• Record Type: Journal Article
• Authors: Amritha, B.; Manaf, O.; Nethaji, M.; Sujith, A.; Prathapachandra Kurup, M.R.; Vasudevan, Suni
• Is Part Of: Polyhedron. Volume 178(2020)
• Publication Date: 2020-03-01
• Subjects: Mn(II) thiosemicarbazone complex -- DNA binding -- Antibacterial -- Naked-eye detection -- Sensing of metal ions; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2019.114333
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: A manganese(II) complex of di-2-pyridyl ketone N (4)-phenyl thiosemicarbazone (HL) was synthesized and fully characterized using single crystal X-ray diffraction studies and spectroscopic measurements. The DNA binding capabilities of the ligand and the complex were assessed using absorption titrations, fluorescent intercalator displacement assays and viscosity measurements. The antimicrobial activities of the compounds were also evaluated and the complex exhibited higher antibacterial activity compared to the ligand HL. The complex also exhibited a colorimetric sensing property, working as an excellent probe for the naked-eye detection of Fe 2+ and Ru 3+ ions with a visible color change from yellow to colorless. Abstract: A novel manganese(II) complex of a di-2-pyridyl ketone N (4)-phenyl thiosemicarbazone (HL) was synthesized and characterized. Single crystal X-ray diffraction studies revealed that the asymmetric unit of the triclinic unit cell contained two independent Mn(L)2 molecules together with two water molecules of crystallization and a DMF molecule. DNA binding studies of the ligand and its complex were conducted using absorption titrations, fluorescent intercalator displacement assays and viscosity measurements. Both the ligand and the complex were found to show good DNA binding abilities and actively displaced the standard intercalator ethidium bromide. In addition to the DNA binding studies, antimicrobial activities of the compounds were also determined and the complex exhibited higher antibacterial activity compared to the ligand HL. Another interesting property exhibited by the manganese complex was its colorimetric sensing, making it an excellent probe for naked-eye detection of Fe 2+ and Ru 3+ ions, with a visible color change from yellow to colorless. The recognition ability of the ions by the probe was quantitatively analyzed using a titration [ion]/[complex] ratio of 0–2.