Angelicosides I-IV, four undescribed furanocoumarin glycosides from Angelica dahurica roots and their tyrosinase inhibitory activities. (April 2020)

• Record Type: Journal Article
• Authors: Shu, Penghua; Li, Junping; Fei, Yingying; Zhu, Huiqing; Zhang, Lingxiang; Niu, Haoying; Li, Yamin; Liu, Hao; Ju, Zhiyu; Wei, Xialan; Xiao, Fugang; Xu, Zhihong
• Is Part Of: Phytochemistry letters. Volume 36(2020)
• Page Start: 32
• Page End: 36
• Publication Date: 2020-04
• Subjects: Angelica dahurica -- Apiaceae -- Furanocoumarin -- Rhamnoside -- Angelicoside -- Tyrosinase; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.01.006
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: The first report about furanocoumarin rhamnosides from Angelica dahurica roots. Four new furanocoumarin glycosides and eight known compounds from this plant. Acid hydrolysis and enzymatic hydrolysis were used to elucidate the absolute configurations of new compounds. The mushroom tyrosinase inhibitory activities of isolated compounds were tested. Abstract: Angelica dahurica is an important medicinal plant, which has been widely used in medicines and skin-whitening products. In the investigation of phytochemicals present in A. dahurica roots, three unusual furanocoumarin rhamnosides, angelicosides I–III (1 –3 ), one undescribed furanocoumarin glucoside, angelicoside IV (4 ), together with eight known compounds (5 –12 ) were isolated. Their structures were characterized by a combination of UV, IR, NMR, HRESIMS, along with acid hydrolysis and enzymatic hydrolysis. All the isolated compounds were tested for their mushroom tyrosinase inhibitory activities, and compounds 1, 2, and 11 showed moderate activities.