Lanicepsides C-E from the aerial part of Clematis chinensis Osbeck. (June 2020) - Sun, Ye
Graphical abstract: Highlights: Three new phenylpropanoids and twenty-two known compounds were isolated and identified. Thirteen known compounds were isolated from Clematis chinensis Osbeck for the first time. Structures of new constituents and cytotoxicity activities were elaborated and provided. Abstract: Three new phenylpropanoids (lanicepsides C–E, 1–3 ) and twenty-two (4-25 ) known ones were isolated from the aerial part of Clematis chinensis Osbeck. Structure elucidation was performed by several spectroscopic techniques, including one and two-dimensional NMR spectra and HRESIMS. Compounds 4, 5, 8, 11–17 and 19 -21 were reported from Clematis chinensis Osbeck for the first time. All compounds were tested for cytotoxic activity against three cancer cell lines (HeLa, MGC-803, Ishikawa) by MTT assay. The results showed that compounds 4–7 (IC50 values in the range of 10.1±1.1–22.3±1.9 μM) displayed medium cytotoxicity against Ishikawa cells.