Integrated molecular imaging technologies for investigation of metals in biological systems: A brief review. (April 2020)

• Record Type: Journal Article
• Authors: Perry, William J.; Weiss, Andy; Van de Plas, Raf; Spraggins, Jeffrey M.; Caprioli, Richard M.; Skaar, Eric P.
• Is Part Of: Current opinion in chemical biology. Volume 55(2020)
• Page Start: 127
• Page End: 135
• Publication Date: 2020-04
• Subjects: Metal imaging -- IMS -- Metallomics -- Multimodal -- Integrated imaging -- 3D imaging -- Molecular imaging -- Image fusion -- Data-driven image fusion -- Imaging mass spectrometry; Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2020.01.008
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract: Metals play an essential role in biological systems and are required as structural or catalytic co-factors in many proteins. Disruption of the homeostatic control and/or spatial distributions of metals can lead to disease. Imaging technologies have been developed to visualize elemental distributions across a biological sample. Measurement of elemental distributions by imaging mass spectrometry and imaging X-ray fluorescence are increasingly employed with technologies that can assess histological features and molecular compositions. Data from several modalities can be interrogated as multimodal images to correlate morphological, elemental, and molecular properties. Elemental and molecular distributions have also been axially resolved to achieve three-dimensional volumes, dramatically increasing the biological information. In this review, we provide an overview of recent developments in the field of metal imaging with an emphasis on multimodal studies in two and three dimensions. We specifically highlight studies that present technological advancements and biological applications of how metal homeostasis affects human health. Graphical abstract: Image 1