Integrating biocatalysis with chemocatalysis for selective transformations. (April 2020)

• Record Type: Journal Article
• Authors: Huang, Xiaoqiang; Cao, Mingfeng; Zhao, Huimin
• Is Part Of: Current opinion in chemical biology. Volume 55(2020)
• Page Start: 161
• Page End: 170
• Publication Date: 2020-04
• Subjects: Biocatalysis -- Chemocatalysis -- Cascade reactions -- Synergistic effect; Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2020.02.004
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract: The integration of biocatalysis with chemocatalysis combines the excellent selectivity of the former with the robust reactivity of the latter and offers many advantages, such as lower cost, higher yield, enhanced selectivity, as well as less waste generation. In spite of the challenge of incompatibilities between different classes of catalysts, recent advances in synthetic chemistry and biology provide ample opportunities for multistep cascade transformations that combine biocatalysis and chemocatalysis. Herein, we review recent progress in merging biocatalysis with chemocatalysis, highlighting selected examples of photo-/electricity-driven biotransformations and recently developed strategies for addressing the catalyst incompatibility issue. Graphical abstract: Image 1 Highlights: Integrating biocatalysis and chemocatalysis has emerged as an attractive strategy for synthesis. Recent advances in synthetic chemistry and biology offer ample opportunities for combining biocatalysis and chemocatalysis. Significant progress has been made in overcoming the catalyst incompatibility challenges.