The chemical biology of hydrogen sulfide and related hydropersulfides: interactions with biologically relevant metals and metalloproteins. (April 2020)

• Record Type: Journal Article
• Authors: Fukuto, Jon M.; Vega, Valeria Suarez; Works, Carmen; Lin, Joseph
• Is Part Of: Current opinion in chemical biology. Volume 55(2020)
• Page Start: 52
• Page End: 58
• Publication Date: 2020-04
• Subjects: Hydropersulfide -- Polysulfide -- Hydrogen sulfide -- Metalloproteins -- Heavy metals -- Sulfur redox; CcO Cytochrome c oxidase -- Mb myoglobin -- SOX sulfur-oxidizing enzyme -- Cys-SSH cysteine hydropersulfide; Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2019.11.013
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract: Hydrogen sulfide and related/derived persulfides (RSn H, RSSn R, n > 1) have been the subject of recent research interest because of their reported physiological signaling roles. In spite of their described actions, the chemical/biochemical mechanisms of activity have not been established. From a chemical perspective, it is likely that metals and metalloproteins are possible biological targets for the actions of these species. Thus, the chemical biology of hydrogen sulfide and persulfides with metals and metalloproteins will be discussed as a prelude to future speculation regarding their physiological function and utility.