Lipid-based biomarkers for CVD, COPD, and aging – A translational perspective. (April 2020)

• Record Type: Journal Article
• Authors: Ekroos, Kim; Lavrynenko, Oksana; Titz, Bjoern; Pater, Calin; Hoeng, Julia; Ivanov, Nikolai V.
• Is Part Of: Progress in lipid research. Volume 78(2020)
• Publication Date: 2020-04
• Subjects: Cardiovascular disease -- Chronic obstructive pulmonary disease -- Aging -- Biomarkers -- Lipidomics; AHA American Heart Association -- AUC area under the curve -- CAD coronary artery disease -- CE cholesteryl ester -- Cer ceramide -- CerS6 ceramide synthase 6 -- COPD chronic obstructive pulmonary disease -- CVD cardiovascular disease -- DAG diacylglycerol -- 11, 12-DHET 11, 12-dihydroxyeicosatrienoic acid -- 14, 15-DHET 14, 15-dihydroxyeicosatrienoic acid -- FA fatty acid -- GM3 GM3 ganglioside -- HDL-C high-density lipoprotein cholesterol -- 15-HETrE 15-hydroxyeicosatrienoic acid -- 9-HODE 9-hydroxyoctadecadienoic acid -- 13-HODE 13-hydroxyoctadecadienoic acid -- LacCer lactosylceramide -- LDL-C low-density lipoprotein cholesterol -- LPC lysophosphatidylcholine -- LPC-O alkyl lysophosphatidylcholine -- LPC-P alkenyl lysophosphatidylcholine -- LPE lysophosphatidylethanolamine -- LPG lysophosphatidylglycerol -- LPI lysophosphatidylinositol -- LTB4 leukotriene B4 -- MAG monoacylglycerol -- MS mass spectrometry -- PC phosphatidylcholine -- PC-O alkyl phosphatidylcholine -- PC-P alkenyl phosphatidylcholine -- PE phosphatidylethanolamine -- PE-O alkyl phosphatidylethanolamine -- PE-P alkenyl phosphatidylethanolamine -- PG phosphatidylglycerol -- PGE2 prostaglandin E2 -- PI phosphatidylinositol -- PS phosphatidylserine -- SM sphingomyelin -- TAG triacylglycerol -- THS Tobacco Heating System -- TMAO trimethylamine N-oxide -- triHexCer trihexosylceramide -- WHO World Health Organization; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipiden; 572.57
• DOI: 10.1016/j.plipres.2020.101030
• Languages: English
• ISSNs: 0163-7827

Abstract

Abstract: For many diseases, there is an unmet need for new or better biomarkers for improved disease risk assessment and monitoring, as available markers lack sufficient specificity. Lipids are drawing major interest as potential candidates for filling these gaps. This has recently been demonstrated by the identification of selective ceramides for prediction of cardiovascular mortality, enabling improved risk assessment of cardiovascular disease compared with conventional clinical markers. In this review, we discuss current lipid biomarker findings and the possible connection between cardiovascular disease, chronic obstructive pulmonary disease, and aging. Moreover, we discuss how to overcome the current roadblocks facing lipid biomarker research. We stress the need for improved quantification, standardization of methodologies, and establishment of initial reference values to allow for an efficient transfer path of research findings into the clinical landscape, and, ultimately, to put newly identified biomarkers into practical use.