Novel bacterial cellulose membrane biosynthesized by a new and highly efficient producer Komagataeibacter rhaeticus TJPU03. (July 2020)

• Record Type: Journal Article
• Authors: He, Xiaoling; Meng, Hongyan; Song, Haode; Deng, Shiyu; He, Tingting; Wang, Shuai; Wei, Dongsheng; Zhang, Zhijun
• Is Part Of: Carbohydrate research. Volume 493(2020)
• Publication Date: 2020-07
• Subjects: Bacterial cellulose -- Komagataeibacter rhaeticus -- production Capability -- Physicochemical property -- Drug release; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2020.108030
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: Bacterial cellulose(BC) is a kind of extracellular polymer synthesized by bacteria and it has very wide applications in many fields. However, the application of BC in a large commercial scale can still not be fulfilled due to the low yield and demanding for BC membranes with very different properties. To this end, a new BC-producer Komagataeibacter rhaeticus TJPU03 was isolated from rotten orange peel, which produced 8.28 ± 0.27 g/L(dry weight) in standard HS medium at the 10th day. The membrane is easier to be purified by one-step alkaline treatment and the produced BC( K - BC ) membranes possess homogeneous, looser and more porous three-dimensional network composed by thinner cellulose fibrils. However, the wet K-BC possesses stronger mechanical properties and exhibits lower toxicity and higher cytocompatibility to mammalian cell. Owing to the more porous and homogeneous network, K-BC possesses high loading capacity of cell and protein drugs. Also, it exhibits sustained-controlled release ability for proteinaceous drug. The high yield of this strain and the special characteristics of K - BC predict this strain to be a very promising BC-producer and broad applications of K-BC in the fields of wound healing, scaffolds of tissue engineering, tissue repair and regeneration. Graphical abstract: Image 1 Highlights: A novel BC producing strain is obtained. BC produced by this strain possesses novel properties. This BC has great potential for drug delivery carrier.