Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey. Issue 5 (May 2020)

• Record Type: Journal Article
• Authors: Pezzilli, Raffaele; Buscarini, Elisabetta; Pollini, Tommaso; Bonamini, Deborah; Marchegiani, Giovanni; Crippa, Stefano; Belfiori, Giulio; Sperti, Cosimo; Moletta, Lucia; Pozza, Gioia; De Nucci, Germana; Manes, Giampiero; Mandelli, Enzo D.; Casadei, Riccardo; Ricci, Claudio; Alicante, Saverio; Vattiato, Claudia; Carrara, Silvia; Di Leo, Milena; Fabbri, Carlo; Giovanelli, Silvia; Barresi, Luca; Tacelli, Matteo; Mirante, Vincenzo G.; Conigliaro, Rita; Antonini, Filippo; Macarri, Giampiero; Frulloni, Luca; De Marchi, Giulia; Sassatelli, Romano; Cecinato, Paolo; Del Vecchio Blanco, Giovanna; Galli, Andrea; Pezzullo, Angelo; Fantin, Alberto; Graffeo, Massimo; Frego, Mauro; Stillittano, Domenico; Monica, Fabio; Germanà, Bastianello; Capurso, Gabriele; Quartini, Mariano; Veneroni, Luigi; Cannizzaro, Renato; Falconi, Massimo;
• Is Part Of: Digestive and liver disease. Volume 52:Issue 5(2020)
• Page Start: 547
• Page End: 554
• Publication Date: 2020-05
• Subjects: Biomarkers -- Cystic neoplasm -- Cytology -- Endosonography -- Epidemiology -- Magnetic resonance imaging -- Multidetector computed tomography -- Pancreatic cyst; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2020.02.003
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Introduction: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines. Methods: An online data sheet was built. Results: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up. Conclusions: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.