Current use and management of commercial fish vaccines in Korea. Issue 102 (July 2020)

• Record Type: Journal Article
• Authors: Hwang, Jee Youn; Kwon, Mun Gyeong; Seo, Jung Soo; Hwang, Seong Don; Jeong, Ji Min; Lee, Ji Hoon; Jeong, Ah Reum; Jee, Bo Young
• Is Part Of: Fish & shellfish immunology. Issue 102(2020)
• Page Start: 20
• Page End: 27
• Publication Date: 2020-07
• Subjects: Fish vaccine -- Olive flounder (Paralichthys olivaceus) -- Bacterial disease -- Approval -- Safety -- Stability -- Effectiveness; EMEM Eagle's minimum essential medium -- EPC extracellular product -- FBA fructose-biphosphate aldose -- FIA Freund's incomplete adjuvant -- FKC formalin-killed cell -- GAPDH glyceraldehyde-3-phosphate dehydrogenase -- SDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresis -- RPS relative percent survival -- VHS viral hemorrhagic septicemia; Fishes -- Immunology -- Periodicals; Shellfish -- Immunology -- Periodicals; Poissons -- Immunologie -- Périodiques; Crustacés -- Immunologie -- Périodiques; 571.9617
• DOI: 10.1016/j.fsi.2020.04.004
• Languages: English
• ISSNs: 1050-4648

Abstract

Abstract: The aquaculture industry in Korea has grown rapidly since the 1960s, and it is a major food source. However, the expansion of aquaculture systems has increased the chances of infectious disease outbreaks, and vaccination plays an important role in commercial fish farming. This is the first comprehensive review of commercial fish vaccines in Korea. It not only provides an overview of commercially available fish vaccines and their associated approval processes and laws, but also some perspectives on research advances regarding fish vaccines in Korea. In Korea, fish vaccines are approved only after their safety and effectiveness have been verified according to the Pharmaceutical Affairs Act, and after approval, each vaccine lot must pass the national evaluation criteria. As of the end of 2019, 29 vaccines were approved for 10 fish pathogens, including both single and combination vaccines containing more than two inactivated pathogens. The approved fish vaccines consist of 2 immersion vaccines, as well as 1 intramuscular and 26 intraperitoneal vaccines, which require syringe injection. All the 29 vaccines are manufactured as formalin-inactivated vaccines; 1 is an adjuvant vaccine and 28 are non-adjuvant vaccines; 25 are bacterial vaccines, 2 are viral vaccines, 1 is a parasite vaccine, and 1 is a parasite and bacterial vaccine. In terms of the target fish species, 27 vaccines are used in the olive flounder ( Paralichthys olivaceus ), 1 in the starry flounder ( Platichthys stellatus ), and 1 in the red seabream ( Pagrus major ), striped beakfish ( Oplegnathus fasciatus ), and amberjack ( Seriola quinqueradiata ). This imbalance exists mostly because the olive flounder is the main farmed fish species in Korea. In 2018, 67.71 million vaccine doses were distributed following satisfactory performance in the national evaluation. They were used to vaccinate approximately 80.6% of farmed olive flounders. Highlights: Vaccines in Korea are approved according to the Pharmaceutical Affairs Act. Twenty-nine vaccines for ten types of fish pathgen are approved and commercialized in Korea. Vaccines for bacterial, parasitic and viral diseases of oliv flounder were already commercialized in Korea.