Lack of association between insulin resistance as estimated by homeostasis model assessment and stroke risk: A systematic review and meta-analysis. (August 2020)

• Record Type: Journal Article
• Authors: Gu, Tianyi; Yang, Qiguo; Ying, Guangyu; Jin, Bo
• Is Part Of: Medical hypotheses. Volume 141(2020)
• Publication Date: 2020-08
• Subjects: Insulin resistance -- HOMA-IR -- Stroke -- Meta-analysis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Medicine; Periodicals; 610
• DOI: 10.1016/j.mehy.2020.109700
• Languages: English
• ISSNs: 0306-9877

Abstract

Abstract: Epidemiologic studies have reported conflicting results on the association between insulin resistance and risk of stroke. This meta-analysis sought to evaluate the association between homeostasis model assessment-insulin resistance (HOMA-IR) and risk of stroke. Eligible studies were identified by searching PubMed and Emabse databases up to December 2018. Prospective observational studies investigating the association between HOMA-IR and incident stroke were included. Seven studies involving 36, 343 participants were identified. The pooled risk ratio (RR) of stroke was 1.29 (95% confidence intervals [CI] 0.89–1.87) for the highest versus the lowest HOMA-IR category. Similarly, individuals with insulin resistance did not significantly increase the risk of ischemic stroke (RR 1.65; 95%CI 0.76–3.56). Likewise, insulin resistance was also not associated with higher risk of stroke in the general population (RR 1.38; 95%CI 0.88–2.18) and non-diabetic population subgroup (RR 1.76; 95%CI 0.71–4.35). This meta-analysis suggests lack of association between HOMA-IR and risk of stroke. However, interpretation of these findings should be with caution due to the small number of studies analyzed and significant heterogeneity across studies.