Copy number variations in miscarriage products and their relationship with consanguinity and recurrent miscarriage in individuals with normal karyotypes. (June 2020)

• Record Type: Journal Article
• Authors: Atefvahid, Parisa; Modarressi, Mohammad Hossein; Aleyasin, Ashraf; Noormohammadi, Zahra
• Is Part Of: Molecular and cellular probes. Volume 51(2020)
• Publication Date: 2020-06
• Subjects: Molecular probes -- Diagnostic use -- Periodicals; Pathology, Cellular -- Technique -- Periodicals; Cell Biology -- Periodicals; Molecular Biology -- Periodicals; Sondes moléculaires -- Utilisation diagnostique -- Périodiques; Cytopathologie -- Technique -- Périodiques; 572
• DOI: 10.1016/j.mcp.2020.101526
• Languages: English
• ISSNs: 0890-8508

Abstract

Highlights: Cause of some miscarriages are copy number variations. Some of CNVs in fetal loss products are beyond traditional karyotyping resolution. Ultrasound-identified defects are the most accurate predictor for presence of CNVs in the fetus. Consanguineous couples are more predisposed to recurrent miscarriage. There is no correlation between copy number variation in subtelomeric regions and miscarriage in consanguineous couples.