Does platelet-rich fibrin increase stability of the maxilla following Le Fort I osteotomy? A single-blind clinical trial study. Issue 6 (June 2020)

• Record Type: Journal Article
• Authors: Tabrizi, Reza; Mirmohammad Sadeghi, Hassan; Bakhshaei, Pedram; Ozkan, Birkan Taha
• Is Part Of: Journal of cranio-maxillofacial surgery. Volume 48:Issue 6(2020)
• Page Start: 531
• Page End: 535
• Publication Date: 2020-06
• Subjects: Maxilla -- Platelet-rich fibrin -- Osteotomy -- Le fort -- Relapse; Skull -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Surgery, Plastic -- Periodicals; Maxilla -- surgery -- Periodicals; Face -- surgery -- Periodicals; Skull -- surgery -- Periodicals; Oral Surgical Procedures -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Surgery, Plastic -- Periodicals; Surgery, Oral -- Periodicals; Electronic journals; 617.514
• DOI: 10.1016/j.jcms.2020.04.007
• Languages: English
• ISSNs: 1010-5182

Abstract

Abstract: This single-blind clinical trial study aimed to assess the efficacy of platelet-rich fibrin (PRF) in increasing stability following Le Fort I osteotomy for maxillary advancement. Patients who underwent Le Fort I osteotomy for maxillary advancement were assigned randomly into two groups: in group 1 (the study group, n = 22) PRF was placed in the osteotomy sites following fixation, while no PRF was used in group 2 (the control group, n = 22). Lateral cephalograms obtained preoperatively (T0), immediately after surgery (T1), and 1 year after surgery (T2) were compared between the two groups, and the amount of relapse was determined. The amount of maxillary change (relapse) at the A point in relation to the x -axis was 0.45 ± 0.67 mm in group 1 and 1.86 ± 0.56 mm in group 2. There was a significant difference in mean relapse in relation to the x -axis between the two groups 12 months after osteotomy ( p < 0.001). The mean maxillary change (relapse) in relation to the y -axis was 0.77 ± 1.15 mm in group 1 and 2.25 ± 1.22 mm in group 2. Analysis of the data demonstrated a significant difference in mean relapse in relation to the y -axis between the two groups ( p < 0.001). PRF may enhance the stability of the maxilla following Le Fort I osteotomy. Based on the results of this study the administration of PRF should be considered whenever possible. Highlights: Stability of the osteotomy segment following Le Fort I osteotomy is crucial for achieving an acceptable result. Platelet-rich fibrin (PRF) enhances bone healing. PRF can significantly decrease the rate of relapse following maxillary advancement at 1 year after Le Fort I osteotomy.