Laparoscopic adrenalectomy (LA) vs open adrenalectomy (OA) for pheochromocytoma (PHEO): A systematic review and meta-analysis. Issue 6 (June 2020)

• Record Type: Journal Article
• Authors: Li, Jingdong; Wang, Yaxuan; Chang, Xueliang; Han, Zhenwei
• Is Part Of: European journal of surgical oncology. Volume 46:Issue 6(2020)
• Page Start: 991
• Page End: 998
• Publication Date: 2020-06
• Subjects: Laparoscopic adrenalectomy -- Open adrenalectomy -- Pheochromocytoma -- Meta-analysis; Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2020.02.009
• Languages: English
• ISSNs: 0748-7983

Abstract

Abstract: Purpose: To evaluate the efficacy and safety of laparoscopic adrenalectomy (LA) vs open adrenalectomy (OA) for pheochromocytoma (PHEO). Methods: A systematic literature research of PubMed, Ovid, Scopus, and citation lists were performed to identify eligible studies. All studies comparing LA versus OA for PHEO were included. Results: Overall, fourteen studies including 743 patients (LA 391; OA 352) were included. LA might have smaller tumor size (WMD -0.92 cm, 95% CI -1.09 to −0.76; p < 0.001) and higher body mass index (BMI) (WMD 0.31 kg/m 2, 95% CI 0.04 to 0.58; p = 0.02). Compared to OA, LA showed lower estimated blood loss (EBL) (WMD -207.72 ml, 95% CI -311.26, −104.19; p < 0.001), lower transfusion rate (OR 0.25, 95% CI 0.16 to 0.38; p < 0.001), lower hemodynamic instability (HI) (OR 0.61, 95% CI 0.42 to 0.88; p = 0.009), less postoperative complications (OR 0.55, 95% CI 0.34 to 0.89; p = 0.02), less Clavien Dindo score ≥3 complications (OR 0.51, 95% CI 0.27 to 0.97; p = 0.04), shorter return to diet time (WMD -0.76 days, 95% CI -1.27 to −0.25; p = 0.003), and shorter length of hospital stay (WMD -1.76 days, 95% CI -2.94 to −0.58; p < 0.001). The subgroup analysis of studies since 2008 showed consistent results. Conclusion: LA shows a feasible, safe and superior treatment option for PHEO, because it provides superior perioperative and recovery outcomes without increasing complications.