Two types of ictal phase-amplitude couplings in epilepsy patients revealed by spectral harmonicity of intracerebral EEG recordings. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Dellavale, Damián; Urdapilleta, Eugenio; Cámpora, Nuria; Velarde, Osvaldo Matías; Kochen, Silvia; Mato, Germán
• Is Part Of: Clinical neurophysiology. Volume 131:Issue 8(2020:Aug.)
• Page Start: 1866
• Page End: 1885
• Publication Date: 2020-08
• Subjects: Phase-amplitude cross frequency coupling -- Spectral harmonicity -- Time locked index -- Epilepsy -- Stereoelectroencephalography; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.04.160
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Harmonic and non harmonic phase-amplitude couplings (PAC) coexist in epileptiform local field potentials. The time locked index quantitatively differentiates harmonic and non harmonic ictal PAC patterns. Spectral harmonicity plays a relevant role in the interpretation of underlying ictal mechanisms. Abstract: Objective: Spectral harmonicity of the ictal activity was analyzed regarding two clinically relevant aspects, (1) as a confounding factor producing 'spurious' phase-amplitude couplings (PAC) which may lead to wrong conclusions about the underlying ictal mechanisms, and (2) its role in how good PAC is in correspondence to the seizure onset zone (SOZ) classification performed by the epileptologists. Methods: PAC patterns observed in intracerebral electroencephalography (iEEG) recordings were retrospectively studied during seizures of seven patients with pharmacoresistant focal epilepsy. The time locked index (TLI) measure was introduced to quantify the degree of harmonicity between frequency bands associated to the emergence of PAC during epileptic seizures. Results: (1) Harmonic and non harmonic PAC patterns coexist during the seizure dynamics in iEEG recordings with macroelectrodes. (2) Harmonic PAC patterns are an emergent property of the periodic non sinusoidal waveform constituting the epileptiform activity. (3) The TLI metric allows to distinguish the non harmonic PAC pattern, which has been previously associated with the ictal core through the paroxysmal depolarizing shifts mechanism of seizure propagation. Conclusions: Our results suggest that the spectral harmonicity of the ictal activity plays a relevant role in the visual analysis of the iEEG recordings performed by the epileptologists to define the SOZ, and that it should be considered for the proper interpretation of ictal mechanisms. Significance: The proposed harmonicity analysis can be used to improve the delineation of the SOZ by reliably identifying non harmonic PAC patterns emerging from fully recruited cortical and subcortical areas.