Validation of an algorithm of time-dependent electro-clinical risk stratification for electrographic seizures (TERSE) in critically ill patients. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Cissé, F.A.; Osman, G.M.; Legros, B.; Depondt, C.; Hirsch, L.J.; Struck, A.F.; Gaspard, N.
• Is Part Of: Clinical neurophysiology. Volume 131:Issue 8(2020:Aug.)
• Page Start: 1956
• Page End: 1961
• Publication Date: 2020-08
• Subjects: Continuous EEG monitoring -- Critical care EEG monitoring -- Nonconvulsive seizures -- Nonconvulsive status epilepticus -- Risk stratification; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.05.031
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Electroclinical risk stratification identifies 95% of acutely ill patients with electrographic seizures. Electroclinical risk stratification reduces continuous EEG monitoring recording time by 67%. Accounting for evolving brain injury will be required to further improve prediction accuracy. Abstract: Objective: The clinical implementation of continuous electroencephalography (CEEG) monitoring in critically ill patients is hampered by the substantial burden of work that it entails for clinical neurophysiologists. Solutions that might reduce this burden, including by shortening the duration of EEG to be recorded, would help its widespread adoption. Our aim was to validate a recently described algorithm of time-dependent electro-clinical risk stratification for electrographic seizure (ESz) (TERSE) based on simple clinical and EEG features. Methods: We retrospectively reviewed the medical records and EEG recordings of consecutive patients undergoing CEEG between October 1, 2015 and September, 30 2016 and assessed the sensitivity of TERSE for seizure detection, as well as the reduction in EEG time needed to be reviewed. Results: In a cohort of 407 patients and compared to full CEEG review, the model allowed the detection of 95% of patients with ESz and 97% of those with electrographic status epilepticus. The amount of CEEG to be recorded to detect ESz was reduced by two-thirds, compared to the duration of CEEG taht was actually recorded. Conclusions: TERSE allowed accurate time-dependent ESz risk stratification with a high sensitivity for ESz detection, which could substantially reduce the amount of CEEG to be recorded and reviewed, if applied prospectively in clinical practice. Significance: Time-dependent electro-clinical risk stratification, such as TERSE, could allow more efficient practice of CEEG and its more widespread adoption. Future studies should aim to improve risk stratification in the subgroup of patients with acute brain injury and absence of clinical seizures.