Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5, 5-dimethylcyclohexane-1, 3-dione. (1st March 2020)

• Record Type: Journal Article
• Authors: Eremina, Julia A.; Lider, Elizaveta V.; Sukhikh, Taisiya S.; Eltsov, Ilia V.; Kuratieva, Natalia V.; Zakharov, Boris A.; Sheludyakova, Liliya A.; Klyushova, Lyubov S.; Ermakova, Ekaterina A.; Dotsenko, Victor V.
• Is Part Of: Polyhedron. Volume 178(2020)
• Publication Date: 2020-03-01
• Subjects: β-Enaminone -- Mononuclear complexes -- Crystal structures -- Cytotoxicity -- Hep-2; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2019.114325
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Reaction of Cu(II), Co(II), Ni(II) and Pd(II) salts with 2-anilinomethylidene-5, 5-dimethylcyclohexane-1, 3-dione produced the coordination compounds of the composition [ML2 (C2 H5 OH)2 ]·nH2 O (M = Co (n = 1), Ni (n = 0)) and [ML2 ] (M = Cu, Pd), whose crystal structures were determined. The cytotoxic properties of the complexes have been investigated in vitro on Hep-2 cell line and the Pd(II) compound showed the highest cytotoxicity. Abstract: The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5, 5-dimethylcyclohexane-1, 3-dione (HL) of the composition [ML2 (C2 H5 OH)2 ]·nH2 O (M = Co (n = 1), Ni (n = 0)) and [ML2 ] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2 (C2 H5 OH)2 ] or square planar [ML2 ]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don't exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9, 2 ± 0, 5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68, 7 ± 5, 3 μM.