HPV vaccine uptake among daughters of Latinx immigrant mothers: Findings from a cluster randomized controlled trial of a community-based, culturally relevant intervention. Issue 25 (22nd May 2020)

• Record Type: Journal Article
• Authors: Scarinci, Isabel C.; Hansen, Barbara; Kim, Young-il
• Is Part Of: Vaccine. Volume 38:Issue 25(2020)
• Page Start: 4125
• Page End: 4134
• Publication Date: 2020-05-22
• Subjects: Latinx immigrants -- HPV vaccination -- Cervical cancer -- Cluster-randomized controlled trial; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2020.03.052
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: Objective: We examined the efficacy of a culturally relevant, community-based HPV vaccination intervention among Latinx immigrant mothers with daughters aged 9–12 in Alabama. Methods: We conducted a cluster-randomized controlled trial with "place of residence" (e.g., apartment complexes, trailer parks) as the unit of randomization that evaluated two interventions: 1) promotion of HPV vaccination and 2) promotion of healthy eating and appropriate nutrition label interpretation. Identical baseline/post/7-month follow up questionnaires were completed by all participants and both interventions consisted of four group sessions and one individual session. A total of 40 locations were randomized with 317 mother-daughter dyads enrolled in the study between May 2013 and October 2017. Results: A total of 278 mother-daughter dyads met full eligibility and initiated the intervention/control participation. Retention rate overall was 93.2% (92.6% for the intervention arm and 93.7% for the control arm). Daughters in the intervention arm were significantly more likely to receive one, two, and three doses of HPV vaccine than daughters in the control arm p < 0.001). In multivariate analyses, mothers in the intervention arm had a six times greater odds of vaccinating daughters with the first dose ( OR = 5.96, 95% CI: 3.38, 10.49), eight times greater odds of vaccinating daughters with the second dose ( OR = 8.09, 95% CI: 4.0, 16.35), and more than 16 times greater odds of completing the three-dose HPV vaccine series than mothers in the control arm after adjusting for mother's age, time in the U.S., income, and daughter's health insurance status ( OR = 16.5, 95% CI: 5.73, 47.48). Only perceived risk of their daughters' future HPV infection remained significant as a predictor of three-dose HPV vaccination completion ( OR = 0.69, 95% CI: 0.23, 2.1). Conclusions: A theory-driven, culturally-relevant intervention developed through extensive formative assessments in collaboration with community members can effectively promote HPV vaccination among 9–12 years of age daughters of Latina immigrants.