Value of circulating miRNA-1 detected within 3 h after the onset of acute chest pain in the diagnosis and prognosis of acute myocardial infarction. (15th May 2020)

• Record Type: Journal Article
• Authors: Su, Tong; Shao, Xiaonan; Zhang, Xiaopu; Yang, Chengjian; Shao, Xiaoliang
• Is Part Of: International journal of cardiology. Volume 307(2020)
• Page Start: 146
• Page End: 151
• Publication Date: 2020-05-15
• Subjects: Acute myocardial infarction -- miRNA-1 -- Diagnosis -- Prognosis -- Value; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2019.09.050
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: To explore the significance of circulating miRNA-1 (miR-1) released within 3 h after the onset of acute chest pain in the diagnosis and prognosis of acute myocardial infarction (AMI). Methods: A total of 337 patients with acute chest pain within 3 h were enrolled in this study and divided into AMI group and non-AMI group. The AMI diagnostic efficacy of miR-1 was determined and compared with that of cardiac troponin I (cTnI). The patients were followed up for 720 d after treatment. The significance of circulating miR-1 in AMI prognosis was assessed using univariate and COX regression analysis. Results: There were 174 patients in AMI group, 163 in non-AMI group. Circulating miR-1 level was significantly higher in AMI group than in non-AMI group ( P < 0.001). The AMI diagnostic efficacy of miR-1 and cTnI were similar ( P > 0.05). We established two AMI diagnostic models, the AUC values of which were larger than that of cTnI or miR-1 ( P < 0.05). When miR-1 combined with CK-MB, cTnI, and other clinical and laboratory parameters (model 2), the AUC was the largest (AUC: 0.961) and had the highest diagnostic efficiency. Circulating miR-1, Killip classification, and treatment method were influencing factors for AMI prognosis ( P < 0.05). Conclusions: Circulating miR-1 within 3 h of acute chest pain has the potential diagnostic value for AMI, and which is an independent risk factor for the prognosis of AMI and can be used to predict AMI prognosis. Highlights: Blood samples were collected within 3 h after the onset of the acute chest pain. Mathematical models for early diagnosis of AMI were established by using miR-1. MiR-1 was one of the independent prognostic factors of AMI.