Auditory attention alterations in migraine: A behavioral and MEG/EEG study. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Masson, Rémy; Lévêque, Yohana; Demarquay, Geneviève; ElShafei, Hesham; Fornoni, Lesly; Lecaignard, Françoise; Morlet, Dominique; Bidet-Caulet, Aurélie; Caclin, Anne
• Is Part Of: Clinical neurophysiology. Volume 131:Issue 8(2020:Aug.)
• Page Start: 1933
• Page End: 1946
• Publication Date: 2020-08
• Subjects: Migraine -- Event-related responses -- Bottom-up attention -- Top-down attention -- Electroencephalography -- Magnetoencephalography; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.05.024
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Migraineurs performed as well as healthy participants in an attention task. However, EEG markers of both bottom-up and top-down attention are increased. Migraine is also associated with a facilitated recruitment of the right temporo-parietal junction. Abstract: Objectives: To evaluate alterations of top-down and/or bottom-up attention in migraine and their cortical underpinnings. Methods: 19 migraineurs between attacks and 19 matched control participants performed a task evaluating jointly top-down and bottom-up attention, using visually-cued target sounds and unexpected task-irrelevant distracting sounds. Behavioral responses and magneto- and electro-encephalography signals were recorded. Event-related potentials and fields were processed and source reconstruction was applied to event-related fields. Results: At the behavioral level, neither top-down nor bottom-up attentional processes appeared to be altered in migraine. However, migraineurs presented heightened evoked responses following distracting sounds (orienting component of the N1 and Re-Orienting Negativity, RON) and following target sounds (orienting component of the N1), concomitant to an increased recruitment of the right temporo-parietal junction. They also displayed an increased effect of the cue informational value on target processing resulting in the elicitation of a negative difference (Nd). Conclusions: Migraineurs appear to display increased bottom-up orienting response to all incoming sounds, and an enhanced recruitment of top-down attention. Significance: The interictal state in migraine is characterized by an exacerbation of the orienting response to attended and unattended sounds. These attentional alterations might participate to the peculiar vulnerability of the migraine brain to all incoming stimuli.