Pharmacology on Target. (April 2020)

• Record Type: Journal Article
• Authors: Kawashima, Agnieszka T.; Newton, Alexandra C.
• Is Part Of: Trends in pharmacological sciences. Volume 41:Number 4(2020)
• Page Start: 227
• Page End: 230
• Publication Date: 2020-04
• Subjects: protein kinases -- kinase inhibitors -- mitosis -- SNAP-tag; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2020.02.002
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Small-molecule inhibitors are a key resource in the cell signaling toolbox. However, because of their global distribution in the cell, they cannot provide a refined understanding of signaling at distinct subcellular locations. Bucko and colleagues have designed a novel tool to localize inhibitors to specific protein scaffolds, opening a new avenue to study localized kinase activity.