DELs Inside Cells. (April 2020)

• Record Type: Journal Article
• Authors: Roy, Animesh; Kodadek, Thomas
• Is Part Of: Trends in pharmacological sciences. Volume 41:Number 4(2020)
• Page Start: 225
• Page End: 227
• Publication Date: 2020-04
• Subjects: DNA-encoded library -- probe discovery -- high-throughput screening -- cellular assay -- cell-penetrating peptide; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2020.01.007
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : DNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment.