Biotransformation study of antidepressant sertraline and its removal during biological wastewater treatment. (15th August 2020)

• Record Type: Journal Article
• Authors: Gornik, Tjasa; Kovacic, Ana; Heath, Ester; Hollender, Juliane; Kosjek, Tina
• Is Part Of: Water research. Volume 181(2020)
• Publication Date: 2020-08-15
• Subjects: Mass spectrometry -- Identification -- Degradation -- Sorption -- Transformation product -- Activated sludge; Water -- Pollution -- Research -- Periodicals; 363.7394
• DOI: 10.1016/j.watres.2020.115864
• Languages: English
• ISSNs: 0043-1354

Abstract

Abstract: Sertraline is one of the most commonly prescribed antidepressants in the last few years. Therefore, it is not surprising that it is regularly detected in wastewaters, surface waters, sediments, biosolids and biota. Effluents from wastewater treatment plants are the main contributors to its presence in the environment. The presented study aims to elucidate the processes involved in its removal, concentrating mainly on sorption and biodegradation during wastewater treatment. We performed our laboratory scale experiments in two sets of experiments: 1) batch biodegradation and sorption experiments and 2) flow-through laboratory scale pilot wastewater treatment bioreactors. The batch experiments revealed that sorption to activated sludge was the leading removal process, eliminating up to 90% of sertraline present in the batches. Biodegradation was however the secondary removal process, influenced by the presence of alternative easily biodegradable carbon sources. We postulated chemical structures of ten detected biotransformation products. Among these, we propose the previously recognized metabolite norsertraline, sertraline ketone and hydroxy-sertraline. All the remaining biotransformation products are herein reported for the first time. The removal efficiency of approximately 94% was determined after the treatment in the flow-through bioreactors. To support our findings, we sampled influents and effluents from two wastewater treatment plants and untreated wastewater from a psychiatric hospital. Removal efficiencies of 81% and 77% were determined, and along with the parent compound sertraline, the presence of eight transformation products was confirmed in the actual wastewaters. Graphical abstract: Image 1 Highlights: Sertraline is mainly removed from wastewater by adsorption. Its biodegradation is influenced by the presence of readily biodegradable carbon. Despite high removal efficiencies sertraline is still reported in the environment. Seven novel biotransformation products are identified. The identified biotransformation products are present in wastewaters.