GORK Channel: A Master Switch of Plant Metabolism?. (May 2020)
- Record Type:
- Journal Article
- Title:
- GORK Channel: A Master Switch of Plant Metabolism?. (May 2020)
- Main Title:
- GORK Channel: A Master Switch of Plant Metabolism?
- Authors:
- Adem, Getnet D.
Chen, Guang
Shabala, Lana
Chen, Zhong-Hua
Shabala, Sergey - Abstract:
- Abstract : Potassium regulates a plethora of metabolic and developmental response in plants, and upon exposure to biotic and abiotic stresses a substantial K + loss occurs from plant cells. The outward-rectifying potassium efflux GORK channels are central to this stress-induced K + loss from the cytosol. In the mammalian systems, signaling molecules such as gamma-aminobutyric acid, G-proteins, ATP, inositol, and protein phosphatases were shown to operate as ligands controlling many K + efflux channels. Here we present the evidence that the same molecules may also regulate GORK channels in plants. This mechanism enables operation of the GORK channels as a master switch of the cell metabolism, thus adjusting intracellular K + homeostasis to altered environmental conditions, to maximize plant adaptive potential. Highlights: GORK channels possess the binding motifs and domains that may enable them to operate as ligand-gated channels. Activity of GORK channels may be modulated by cyclic nucleotides, gamma-aminobutyric acid, G-proteins, protein phosphatases, inositol, and ATP. As all aforesaid molecules are known to operate upstream of plant signaling pathways mediating their adaptation to abiotic stresses, GORK channel may therefore operate as a 'master switch' of the cell metabolism, inhibiting energy-consuming anabolic reactions and saving energy for adaptation and repair. This function of the GORK channel may give species a competitive advantage under energy-limitingAbstract : Potassium regulates a plethora of metabolic and developmental response in plants, and upon exposure to biotic and abiotic stresses a substantial K + loss occurs from plant cells. The outward-rectifying potassium efflux GORK channels are central to this stress-induced K + loss from the cytosol. In the mammalian systems, signaling molecules such as gamma-aminobutyric acid, G-proteins, ATP, inositol, and protein phosphatases were shown to operate as ligands controlling many K + efflux channels. Here we present the evidence that the same molecules may also regulate GORK channels in plants. This mechanism enables operation of the GORK channels as a master switch of the cell metabolism, thus adjusting intracellular K + homeostasis to altered environmental conditions, to maximize plant adaptive potential. Highlights: GORK channels possess the binding motifs and domains that may enable them to operate as ligand-gated channels. Activity of GORK channels may be modulated by cyclic nucleotides, gamma-aminobutyric acid, G-proteins, protein phosphatases, inositol, and ATP. As all aforesaid molecules are known to operate upstream of plant signaling pathways mediating their adaptation to abiotic stresses, GORK channel may therefore operate as a 'master switch' of the cell metabolism, inhibiting energy-consuming anabolic reactions and saving energy for adaptation and repair. This function of the GORK channel may give species a competitive advantage under energy-limiting conditions imposed by environmental stresses and explain a reported increase in GORK transcript levels under abiotic stress conditions. … (more)
- Is Part Of:
- Trends in plant science. Volume 25:Number 5(2020)
- Journal:
- Trends in plant science
- Issue:
- Volume 25:Number 5(2020)
- Issue Display:
- Volume 25, Issue 5 (2020)
- Year:
- 2020
- Volume:
- 25
- Issue:
- 5
- Issue Sort Value:
- 2020-0025-0005-0000
- Page Start:
- 434
- Page End:
- 445
- Publication Date:
- 2020-05
- Subjects:
- GABA -- G-protein -- cyclic nucleotide -- ATP -- potassium efflux channel -- molecular evolution
Botany -- Periodicals
Botanique -- Périodiques
Botany
Periodicals
580.5 - Journal URLs:
- http://www.sciencedirect.com/science/journal/13601385 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.tplants.2019.12.012 ↗
- Languages:
- English
- ISSNs:
- 1360-1385
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 9049.675450
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 13383.xml