Microbiome Metabolite Mimics Accelerate Drug Discovery. Issue 5 (May 2020)

• Record Type: Journal Article
• Authors: Nuzzo, Andrea; Brown, James R.
• Is Part Of: Trends in molecular medicine. Volume 26:Issue 5(2020)
• Page Start: 435
• Page End: 437
• Publication Date: 2020-05
• Subjects: microbiome -- metabolites -- PXR -- IBD -- drug discovery; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2020.03.006
• Languages: English
• ISSNs: 1471-4914

Abstract

Abstract : A recent study by Dvořák et al. supports metabolite mimicry as a drug development strategy. A potent agonist of the human pregnane X receptor (hPXR) was designed from two ligands that are products of the microbial catabolism of tryptophan. Its validity was demonstrated in cellular assays and a murine colitis model expressing hPXR by a significant reduction in inflammation biomarkers.