SJS/TEN 2019: From science to translation. Issue 1 (April 2020)

• Record Type: Journal Article
• Authors: Chang, Wan-Chun; Abe, Riichiro; Anderson, Paul; Anderson, Wanpen; Ardern-Jones, Michael R.; Beachkofsky, Thomas M.; Bellón, Teresa; Biala, Agnieszka K.; Bouchard, Charles; Cavalleri, Gianpiero L.; Chapman, Nicole; Chodosh, James; Choi, Hyon K.; Cibotti, Ricardo R.; Divito, Sherrie J.; Dewar, Karen; Dehaeck, Ulrike; Etminan, Mahyar; Forbes, Diane; Fuchs, Esther; Goldman, Jennifer L.; Holmes, James H.; Hope, Elyse A.; Hung, Shuen-Iu; Hsieh, Chia-Ling; Iovieno, Alfonso; Jagdeo, Julienne; Kim, Mee Kum; Koelle, David M.; Lacouture, Mario E.; Le Pallec, Sophie; Lehloenya, Rannakoe J.; Lim, Robyn; Lowe, Angie; McCawley, Jean; McCawley, Julie; Micheletti, Robert G.; Mockenhaupt, Maja; Niemeyer, Katie; Norcross, Michael A.; Oboh, Douglas; Olteanu, Cristina; Pasieka, Helena B.; Peter, Jonathan; Pirmohamed, Munir; Rieder, Michael; Saeed, Hajirah N.; Shear, Neil H.; Shieh, Christine; Straus, Sabine; Sukasem, Chonlaphat; Sung, Cynthia; Trubiano, Jason A.; Tsou, Sheng-Ying; Ueta, Mayumi; Volpi, Simona; Wan, Chen; Wang, Hongsheng; Wang, Zhao-Qing; Weintraub, Jessica; Whale, Cindy; Wheatley, Lisa M.; Whyte-Croasdaile, Sonia; Williams, Kristina B.; Wright, Galen; Yeung, Sonia N.; Zhou, Li; Chung, Wen-Hung; Phillips, Elizabeth J.; Carleton, Bruce C.;
• Is Part Of: Journal of dermatological science. Volume 98:Issue 1(2020)
• Page Start: 2
• Page End: 12
• Publication Date: 2020-04
• Subjects: ADR Adverse drug reaction -- AIDS Acquired immunodeficiency syndrome -- ALDEN Algorithm of drug causality for epidermal necrolysis -- ALK Anaplastic lymphoma kinase -- AUS-SCAR Australian registry of severe cutaneous adverse reactions -- CBZ Carbamazepine -- CFH Complement factor H -- CLET Cultivated limbal epithelial sell transplantation -- COMET Cultivated oral mucosal epithelial transplantation -- CPNDS Canadian Pharmacogenomics Network for Drug Safety -- DILI Drug-induced liver injury -- DRESS Drug reaction with eosinophilia and systemic symptoms -- EHR Electronic health records -- EMA European Medicines Agency -- EpiPGx Epilepsy Pharmacogenomics -- eRMR Electronic Reaction Monitoring Report -- FDA Food and Drug Administration -- GWAS Genome-wide association study -- HIV Human immunodeficiency virus -- HLA Human leukocyte antigen -- IVIg Intravenous immune globulin -- iSCAR International Congress on Cutaneous Adverse Drug Reaction -- ITCH International Consortium on Drug Hypersensitivity -- LSCD Limbal stem cell deficiency -- MPE Maculopapular eruption -- NATIENS North American Therapeutics in Epidermal Necrolysis Syndrome Network -- PGx Pharmacogenomics -- PMDA Pharmaceuticals and Medical Devices Agency (in Japan) -- PRAC Pharmacovigilance Risk Assessment Committee -- QOL Quality of life -- RegiSCAR Multinational registry of Severe Cutaneous Adverse Reactions to drugs and collection of biological samples -- SCAR Severe cutaneous adverse reaction -- SDH Society of Dermatology Hospitalists -- SEAPharm Southeast Asian Pharmacogenomic Network -- SOMET Simple oral mucosal epithelial transplantation -- SJS Stevens-Johnson syndrome -- TB Tuberculosis -- TCR T cell receptor -- TEN Toxic epidermal necrolysis -- TFDA Taiwan Food and Drug Administration -- T-SCAR Taiwan Severe Cutaneous Adverse Reaction Consortium; Stevens-Johnson syndrome (SJS) -- Toxic epidermal necrolysis (TEN) -- Human leukocyte antigen (HLA) -- Pharmacogenomics -- Pharmacovigilance -- Severe cutaneous adverse reaction (SCAR); Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2020.02.003
• Languages: English
• ISSNs: 0923-1811

Abstract

Abstract: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26–27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs.