Endobronchial mucosal nodular lesions in allergic bronchopulmonary aspergillosis. (2020)

• Record Type: Journal Article
• Authors: Nihashi, Fumiya; Hiramatsu, Toshiya; Uto, Tomohiro; Sato, Jun; Imokawa, Shiro; Suda, Takafumi
• Is Part Of: Respiratory medicine case reports. Volume 29(2020)
• Publication Date: 2020
• Subjects: Aspergillus fumigatus -- Eosinophilic granulomatosis with polyangiitis -- Eosinophilic pneumonia -- Mucoid impaction; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2019.100975
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Bronchoscopic findings often show mucoid impaction in patients with allergic bronchopulmonary aspergillosis (ABPA); however, endobronchial mucosal nodular lesions have not been reported. We herein present the first such case of a 52-year-old woman with ABPA with endobronchial mucosal nodular lesions. The endobronchial lesions were located in the orifice of the mucoid impaction, and disappeared after 4 weeks of treatment with prednisolone and itraconazole. Aspergillus fumigatus was cultured from bronchial lavage fluid collected from the site of mucoid impaction. Based on these clinical findings, we speculate that the bronchial lesions were caused by an inflammatory and allergic reaction to Aspergillus antigens.