Does mucosal inflammation drive recurrence of primary sclerosing cholangitis in liver transplantion recipients with ulcerative colitis?. Issue 5 (May 2020)

• Record Type: Journal Article
• Authors: Dekkers, Nik; Westerouen van Meeteren, Menso; Wolterbeek, Ron; Farina Sarasqueta, Arantza; Laleman, Wim; Inderson, Akin; Desschans, Bruno; van Hoek, Bart; Sebib Korkmaz, Kerem; Vermeire, Severine; Maljaars, Jeroen
• Is Part Of: Digestive and liver disease. Volume 52:Issue 5(2020)
• Page Start: 528
• Page End: 533
• Publication Date: 2020-05
• Subjects: Geboes -- IBD -- Mucosal inflammation -- Risk factors -- rPSC; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2020.02.006
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: Liver transplantation remains the only effective evidence based treatment for advanced primary sclerosing cholangitis. However, recurrence of disease occurs in approximately 18%. Aims: This study aimed to assess risk factors of recurrence of primary sclerosing cholangitis. Methods: A retrospective cohort study was performed on patients undergoing transplantation for recurrence of primary sclerosing cholangitis in two academic centers (Leuven, Belgium and Leiden, The Netherlands). Besides other risk factors, the degree of mucosal inflammation was assessed as a potential risk factor using histological Geboes scores. Results: 81 patients were included, of which 62 (76.5%) were diagnosed with ulcerative colitis. Seventeen patients (21.0%) developed rPSC during a median follow-up time of 5.2 years. In a subset of 42 patients no association was found between the degree of mucosal inflammation and recurrence, using both original Geboes scores and multiple cut-off points. In the total cohort, cytomegaloviremia post-transplantation (HR: 4.576, 95%CI 1.688–12.403) and younger receiver age at time of liver transplantation (HR: 0.934, 95%CI 0.881–0.990) were independently associated with an increased risk of recurrence of disease. Conclusion: This study found no association between the degree of mucosal inflammation and recurrence of primary sclerosing cholangitis. An association with recurrence was found for cytomegaloviremia post-liver transplantation and younger age at time of liver transplantation.